Negative Correlation of Serum Adiponectin Levels With Carotid–Femoral Pulse Wave Velocity in Patients Treated With Hemodialysis

Purpose: The aim of this study was to evaluate the relationship between serum adiponectin levels and carotid–femoral pulse wave velocity (cfPWV) in hemodialysis (HD) patients. Method: Blood samples were obtained from 120 HD patients. cfPWV was measured with a validated tonometry system (SphygmoCor; AtCor Medical, West Ryde, Australia). Serum adiponectin levels were measured using a commercially available enzyme-linked immunosorbent assay kit. Results: By univariate linear analysis of cfPWV in HD patients, we found that diabetes (r =.281, p =.002), pre-HD body weight (r =.194, p =.033), post-HD body weight (r =.192, p =.036), waist circumference (r =.210, p =.022), and body fat mass (r =.194, p =.034) were positively correlated, whereas adiponectin level (r = −.254, p =.005) was negatively correlated with cfPWV in HD patients. Multivariate forward stepwise linear regression analysis showed that diabetes (β =.274, p =.006) and adiponectin level (β = −.215, p =.016) were independent predictors of cfPWV in HD patients. Moreover, post-HD body weight (β = −.274, p =.041), waist circumference (β = −.311, p <.001), logarithmically transformed triglyceride level (log-TG; β = −.186, p =.031), and log-glucose (β = −.225, p =.008) were negatively associated with adiponectin levels in HD patients after multivariable forward stepwise linear regression analysis. Conclusions: Among HD patients, serum adiponectin level was inversely associated with cfPWV level, and post-HD body weight, waist circumference, log-TG, and log-glucose were negatively associated with adiponectin level.