Personal profile
Education
1992/09-1996/06 B.Sc. Chemical Engineering, National Cheng Kung University, Taiwan
1996/09-1998/06 M.Sc. Chemical Engineering, National Cheng Kung University, Taiwan
2002/09-2008/10 Ph.D. Biomedical Engineering, National Yang-Ming University, Taiwan
1996/09-1998/06 M.Sc. Chemical Engineering, National Cheng Kung University, Taiwan
2002/09-2008/10 Ph.D. Biomedical Engineering, National Yang-Ming University, Taiwan
Professional Information
2008/11-2011/07. Postdoctoral Fellow, National Yang Ming University, Taiwan
2010/10-2011/03. Visiting Researcher, Free University, Berlin, Germany (DAAD scholarship holder)
2011/08-2015/01. Assistant Professor, Department of Life Sciences, Tzu Chi University, Hualien, Taiwan
2015/02-2021/01. Associate Professor, Department of Life Sciences, Tzu Chi University, Hualien, Taiwan
2021/02- Professor, Department of Life Sciences, Tzu Chi University, Hualien, Taiwan
2021/08- Chair, Department of Life Sciences, Tzu Chi University, Hualien
2010/10-2011/03. Visiting Researcher, Free University, Berlin, Germany (DAAD scholarship holder)
2011/08-2015/01. Assistant Professor, Department of Life Sciences, Tzu Chi University, Hualien, Taiwan
2015/02-2021/01. Associate Professor, Department of Life Sciences, Tzu Chi University, Hualien, Taiwan
2021/02- Professor, Department of Life Sciences, Tzu Chi University, Hualien, Taiwan
2021/08- Chair, Department of Life Sciences, Tzu Chi University, Hualien
Award
103學年度、104學年度、106學年度、108學年度、109學年度、110學年度慈濟大學論文獎
Research Interests
1. Computer-aided drug design, molecular docking, and molecular dynamics simulations
2. GPCR structural dynamics simulation and activation mechanism
3. Nanoparticles design, formation, and applications in biomedicine
4. Biomaterials
2. GPCR structural dynamics simulation and activation mechanism
3. Nanoparticles design, formation, and applications in biomedicine
4. Biomaterials
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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國科會: Accelerated molecular dynamics simulation study on ligand-binding and activation mechanisms of GABAB heterodimer in complex with G protein and its application on novel scaffold drug discovery (II)(III)
Hsu, H.-J. (PI)
1/08/25 → 31/07/26
Project: Research Project › A.Government Departments > a.National Science and Technology Council
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國科會: Accelerated molecular dynamics simulation study on ligand-binding and activation mechanisms of GABAB heterodimer in complex with G-protein and its application on novel scaffold drug discovery
Hsu, H.-J. (PI)
1/08/24 → 31/07/25
Project: Research Project › A.Government Departments > a.National Science and Technology Council
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Molecular simulation study on the molecular activation mechanism and internal signal transmission of dopamine receptors in complex with G-protein or arrestin(3/3)
Hsu, H.-J. (PI)
1/08/23 → 31/07/24
Project: Research Project › A.Government Departments > a.National Science and Technology Council
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慈濟醫療志業: 結構為基礎之胜肽設計與改良以抑制IL-10相關惡性腫瘤之研究(3/3)
Hsu, H.-J. (PI)
1/01/23 → 31/12/23
Project: Research Project › C.Other Units
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科技部: Molecular simulation study on the molecular activation mechanism and internal signal transmission of dopamine receptors in complex with G-protein or arrestin(2/3)
Hsu, H.-J. (PI)
1/08/22 → 31/07/23
Project: Research Project › A.Government Departments > a.National Science and Technology Council
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Allosteric control and water-assisted signaling in activated dopamine receptors upon G protein coupling
Lai, X. Y., Chang, C. C. & Hsu, H. J., Mar 2026, In: International Journal of Biological Macromolecules. 350, 151022.Research output: Contribution to journal › Article › peer-review
Open Access -
Lytic IFNγ is stored in cytotoxic granules and coreleased with granzyme B to mediate cytotoxic T lymphocyte killing
Li, X., Schirra, C., Wirkner, M. L., Tu, S. M., Lin, C. H., Hohmann, M., Gu, Y., Santiago, L., Pardo, J., Arretxe, I., Alawar, N., Chouaib, A. A., Becherer, U., Lee, P. H., Hsu, H. J., Laschke, M. W., Baldari, C. T., Dustin, M. L., Rettig, J. & Krause, E. & 1 others, , Apr 2026, In: Cellular and Molecular Immunology. 23, 4, p. 400-416 17 p.Research output: Contribution to journal › Article › peer-review
Open Access -
An in silico designed peptide-loaded hydrogel is able to accelerate the healing of bacteria-infected wounds in mice
Yang, C. H., Hsu, H. J., Liou, J. W., Chen, G. T., Lai, X. Y., Chuang, C. H. & Chang, C. C., Jan 2025, In: Materials Today Chemistry. 43, 102478.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Deciphering the Activation Mechanism and Internal Signaling Pathways of Dopamine Receptor D1 bound with Various Ligands via Molecular Simulations
Lai, X. Y., Hsu, H. J. & Chang, C. C., 2025, 2025 47th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2025 - Proceedings. Institute of Electrical and Electronics Engineers Inc., (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review
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Therapeutic peptides and their delivery using lipid-based nanoparticles
Yen, J. H., Chang, C. C., Wu, T. Y., Yang, C. H., Hsu, H. J. & Liou, J. W., 1 Jul 2025, In: Tzu Chi Medical Journal. 37, 3, p. 223-234 12 p.Research output: Contribution to journal › Review article › peer-review
Open Access9 Scopus citations